Sonic Hedgehog Guides Axons via Zipcode Binding Protein 1-Mediated Local Translation

Sonic hedgehog (Shh) attracts spinal cord commissural axons toward the floorplate. How Shh elicits changes in the growth cone cytoskeleton that drive growth cone turning is unknown. We find that the turning of rat commissural axons up a Shh gradient requires protein synthesis. In particular, Shh sti...

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Publicado en:J Neurosci
Autores principales: Lepelletier, Léa, Langlois, Sébastien D., Kent, Christopher B., Welshhans, Kristy, Morin, Steves, Bassell, Gary J., Yam, Patricia T., Charron, Frédéric
Formato: Artigo
Lenguaje:Inglês
Publicado: Society for Neuroscience 2017
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Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6589976/
https://ncbi.nlm.nih.gov/pubmed/28073938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3016-16.2016
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