Sonic Hedgehog Guides Axons via Zipcode Binding Protein 1-Mediated Local Translation

Sonic hedgehog (Shh) attracts spinal cord commissural axons toward the floorplate. How Shh elicits changes in the growth cone cytoskeleton that drive growth cone turning is unknown. We find that the turning of rat commissural axons up a Shh gradient requires protein synthesis. In particular, Shh sti...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Lepelletier, Léa, Langlois, Sébastien D., Kent, Christopher B., Welshhans, Kristy, Morin, Steves, Bassell, Gary J., Yam, Patricia T., Charron, Frédéric
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6589976/
https://ncbi.nlm.nih.gov/pubmed/28073938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3016-16.2016
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