SR9009 has REV-ERB–independent effects on cell proliferation and metabolism

The nuclear receptors REV-ERBα and -β link circadian rhythms and metabolism. Like other nuclear receptors, REV-ERB activity can be regulated by ligands, including naturally occurring heme. A putative ligand, SR9009, has been reported to elicit a range of beneficial effects in healthy as well as dise...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Dierickx, Pieterjan, Emmett, Matthew J., Jiang, Chunjie, Uehara, Kahealani, Liu, Manlu, Adlanmerini, Marine, Lazar, Mitchell A.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2019
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6589768/
https://ncbi.nlm.nih.gov/pubmed/31127047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1904226116
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