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Cyclin C directly stimulates Drp1 GTP affinity to mediate stress-induced mitochondrial hyperfission
Mitochondria exist in an equilibrium between fragmented and fused states that shifts heavily toward fission in response to cellular damage. Nuclear-to-cytoplasmic cyclin C relocalization is essential for dynamin-related protein 1 (Drp1)–dependent mitochondrial fission in response to oxidative stress...
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| Publicado no: | Mol Biol Cell |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Cell Biology
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6589575/ https://ncbi.nlm.nih.gov/pubmed/30516433 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E18-07-0463 |
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