Cyclin C directly stimulates Drp1 GTP affinity to mediate stress-induced mitochondrial hyperfission

Mitochondria exist in an equilibrium between fragmented and fused states that shifts heavily toward fission in response to cellular damage. Nuclear-to-cytoplasmic cyclin C relocalization is essential for dynamin-related protein 1 (Drp1)–dependent mitochondrial fission in response to oxidative stress...

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Библиографические подробности
Опубликовано в: :Mol Biol Cell
Главные авторы: Ganesan, Vidyaramanan, Willis, Stephen D., Chang, Kai-Ti, Beluch, Samuel, Cooper, Katrina F., Strich, Randy
Формат: Artigo
Язык:Inglês
Опубликовано: The American Society for Cell Biology 2019
Предметы:
Brief Reports
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6589575/
https://ncbi.nlm.nih.gov/pubmed/30516433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E18-07-0463
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