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A map of constrained coding regions in the human genome
Deep catalogs of genetic variation from thousands of humans enable the detection of intraspecies constraint by identifying coding regions with a scarcity of variation. While existing techniques summarize constraint for entire genes, single gene-wide metrics conceal regional constraint variability wi...
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| Publicat a: | Nat Genet |
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| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6589356/ https://ncbi.nlm.nih.gov/pubmed/30531870 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-018-0294-6 |
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