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Discovery of Small Molecule Ligands for MALAT1 by Tuning an RNA-Binding Scaffold
Structural studies of the 3′-end of the oncogenic long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) confirmed a unique triple-helix structure. This structure enables accumulation of the transcript, and high levels of MALAT1 are found in several cancers. Here, we syn...
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| Publicat a: | Angew Chem Int Ed Engl |
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| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6589350/ https://ncbi.nlm.nih.gov/pubmed/30134013 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201808823 |
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