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Discovery of Small Molecule Ligands for MALAT1 by Tuning an RNA-Binding Scaffold
Structural studies of the 3′-end of the oncogenic long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) confirmed a unique triple-helix structure. This structure enables accumulation of the transcript, and high levels of MALAT1 are found in several cancers. Here, we syn...
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| Publicado no: | Angew Chem Int Ed Engl |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6589350/ https://ncbi.nlm.nih.gov/pubmed/30134013 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201808823 |
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