MEK Inhibition Targets Cancer Stem Cells and Impedes Migration of Pancreatic Cancer Cells In Vitro and In Vivo

Pancreatic ductal adenocarcinoma (PDAC) remains a devastating disease with a very poor prognosis. At the same time, its incidence is on the rise, and PDAC is expected to become the second leading cause of cancer-related death by 2030. Despite extensive work on new therapeutic approaches, the median...

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Pubblicato in:Stem Cells Int
Autori principali: Walter, Karolin, Tiwary, Kanishka, Trajkovic-Arsic, Marija, Hidalgo-Sastre, Ana, Dierichs, Laura, Liffers, Sven T., Gu, Jiangning, Gout, Johann, Schulte, Lucas-Alexander, Münch, Jan, Seufferlein, Thomas, Sainz, Bruno, Siveke, Jens T., Rodriguez-Aznar, Eva, Hermann, Patrick C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Hindawi 2019
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6589314/
https://ncbi.nlm.nih.gov/pubmed/31281387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/8475389
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