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Naked Replication Forks Break apRPArt
Stalled replication forks occasionally collapse, leading to potentially catastrophic DNA double-strand breaks. Now, Toledo et al. (2013) reveal that fork breakage occurs when the pool of the single-strand DNA-binding protein RPA becomes exhausted. This study has important implications for the origin...
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| Udgivet i: | Cell |
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| Main Authors: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6589161/ https://ncbi.nlm.nih.gov/pubmed/24267882 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.10.049 |
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