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The HIF-1α/LC3-II Axis Impacts Fungal Immunity in Human Macrophages

The fungal pathogen Histoplasma capsulatum causes a spectrum of disease, ranging from local pulmonary infection to disseminated disease. The organism seeks residence in macrophages, which are permissive for its survival. Hypoxia-inducible factor 1α (HIF-1α), a principal regulator of innate immunity...

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Detalhes bibliográficos
Publicado no:Infect Immun
Main Authors: Friedrich, Dirk, Zapf, Dorinja, Lohse, Björn, Fecher, Roger A., Deepe, George S., Rupp, Jan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6589057/
https://ncbi.nlm.nih.gov/pubmed/31036602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00125-19
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