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Methods to adjust for multiple comparisons in the analysis and sample size calculation of randomised controlled trials with multiple primary outcomes

BACKGROUND: Multiple primary outcomes may be specified in randomised controlled trials (RCTs). When analysing multiple outcomes it’s important to control the family wise error rate (FWER). A popular approach to do this is to adjust the p-values corresponding to each statistical test used to investig...

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Pubblicato in:BMC Med Res Methodol
Autori principali: Vickerstaff, Victoria, Omar, Rumana Z., Ambler, Gareth
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6588937/
https://ncbi.nlm.nih.gov/pubmed/31226934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12874-019-0754-4
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