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Methods to adjust for multiple comparisons in the analysis and sample size calculation of randomised controlled trials with multiple primary outcomes

BACKGROUND: Multiple primary outcomes may be specified in randomised controlled trials (RCTs). When analysing multiple outcomes it’s important to control the family wise error rate (FWER). A popular approach to do this is to adjust the p-values corresponding to each statistical test used to investig...

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Detalhes bibliográficos
Publicado no:BMC Med Res Methodol
Main Authors: Vickerstaff, Victoria, Omar, Rumana Z., Ambler, Gareth
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6588937/
https://ncbi.nlm.nih.gov/pubmed/31226934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12874-019-0754-4
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