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Lack of the hyaluronan receptor CD44 affects the course of bacterial otitis media and reduces leukocyte recruitment to the middle ear

BACKGROUND: CD44 is a multifunctional molecule that plays major roles in both leukocyte recruitment and tissue proliferation. Since mucosal hyperplasia and leukocyte infiltration of the middle ear cavity are major features of otitis media, we evaluated the role of CD44 in the pathophysiology and cou...

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Pubblicato in:BMC Immunol
Autori principali: Lim, Hyun Woo, Pak, Kwang, Kurabi, Arwa, Ryan, Allen F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6588864/
https://ncbi.nlm.nih.gov/pubmed/31226944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12865-019-0302-3
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