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Nucleosome Crowding in Chromatin Slows the Diffusion but Can Promote Target Search of Proteins
Dynamics of nuclear proteins in crowded chromatin has only been poorly understood. Here, we address the diffusion, target search, and structural dynamics of three proteins in a model chromatin using coarse-grained molecular simulations run on the K computer. We prepared two structures of chromatin m...
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| Publicado no: | Biophys J |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Biophysical Society
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6588829/ https://ncbi.nlm.nih.gov/pubmed/31151739 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2019.05.007 |
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