High frequency of pathogenic germline variants within homologous recombination repair in patients with advanced cancer

Genomic screening of cancer patients for predisposing variants is traditionally based on age at onset, family history and type of cancer. Whereas the clinical guidelines have proven efficient in identifying families exhibiting classical attributes of hereditary cancer, the frequency of patients with...

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Publicado no:NPJ Genom Med
Main Authors: Bertelsen, Birgitte, Tuxen, Ida Viller, Yde, Christina Westmose, Gabrielaite, Migle, Torp, Mathias Husted, Kinalis, Savvas, Oestrup, Olga, Rohrberg, Kristoffer, Spangaard, Iben, Santoni-Rugiu, Eric, Wadt, Karin, Mau-Sorensen, Morten, Lassen, Ulrik, Nielsen, Finn Cilius
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6588611/
https://ncbi.nlm.nih.gov/pubmed/31263571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41525-019-0087-6
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