A hydrogel engineered to deliver minocycline locally to the injured cervical spinal cord protects respiratory neural circuitry and preserves diaphragm function

We tested a biomaterial-based approach to preserve the critical phrenic motor circuitry that controls diaphragm function by locally delivering minocycline hydrochloride (MH) following cervical spinal cord injury (SCI). MH is a clinically-available antibiotic and anti-inflammatory drug that targets a...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Neurobiol Dis
Prif Awduron: Ghosh, Biswarup, Nong, Jia, Wang, Zhicheng, Urban, Mark W., Heinsinger, Nicolette M., Trovillion, Victoria A., Wright, Megan C., Lepore, Angelo C., Zhong, Yinghui
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2019
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6588451/
https://ncbi.nlm.nih.gov/pubmed/31028873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2019.04.014
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