Eosinophilia and reduced STAT3 signaling affect neutrophil cell death in autosomal‐dominant Hyper‐IgE syndrome

The autosomal‐dominant hyper‐IgE syndrome (HIES), caused by mutations in STAT3, is a rare primary immunodeficiency that predisposes to mucocutaneous candidiasis and staphylococcal skin and lung infections. This infection phenotype is suggestive of defects in neutrophils, but data on neutrophil funct...

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Vydáno v:Eur J Immunol
Hlavní autoři: Farmand, Susan, Kremer, Bernhard, Häffner, Monika, Pütsep, Katrin, Bergman, Peter, Sundin, Mikael, Ritterbusch, Henrike, Seidl, Maximilian, Follo, Marie, Henneke, Philipp, Henriques‐Normark, Birgitta
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2018
Témata:
Immunity to infection
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6587726/
https://ncbi.nlm.nih.gov/pubmed/30315710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201847650
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