Structural principles that enable oligomeric small heat-shock protein paralogs to evolve distinct functions

Oligomeric proteins assemble with remarkable selectivity, even in the presence of closely related proteins, in order to perform their cellular roles. We show that most proteins related by gene duplication of an oligomeric ancestor have evolved to avoid hetero-oligomerization, and that this correlate...

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Publicado en:Science
Main Authors: Hochberg, Georg K.A., Shepherd, Dale A., Marklund, Erik G., Santhanagoplan, Indu, Degiacomi, Matteo T., Laganowksy, Arthur, Allison, Timothy M., Basha, Eman, Marty, Michael T., Galpin, Martin R., Struwe, Weston B., Baldwin, Andrew J., Vierling, Elizabeth, Benesch, Justin L.P.
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6587588/
https://ncbi.nlm.nih.gov/pubmed/29472485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aam7229
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