A population pharmacokinetic study of benzathine benzylpenicillin G administration in children and adolescents with rheumatic heart disease: new insights for improved secondary prophylaxis strategies

BACKGROUND: Benzathine benzylpenicillin G (BPG) is recommended as secondary prophylaxis to prevent recurrence of acute rheumatic fever and subsequent rheumatic heart disease (RHD). Following intramuscular injection, BPG is hydrolysed to benzylpenicillin. Little is known of the pharmacokinetics of be...

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Detalles Bibliográficos
Publicado en:J Antimicrob Chemother
Main Authors: Hand, Robert M, Salman, Sam, Newall, Nelly, Vine, Julie, Page-Sharp, Madhu, Bowen, Asha C, Gray, Katherine, Baker, Amy, Kado, Joseph, Joseph, John, Marsh, Julie, Ramsay, James, Sika-Paotonu, Dianne, Batty, Kevin T, Manning, Laurens, Carapetis, Jonathan
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2019
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Original Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6587412/
https://ncbi.nlm.nih.gov/pubmed/30989171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkz076
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