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Delayed insulin absorption correlates with alterations in subcutaneous depot kinetics in rats with diet‐induced obesity

OBJECTIVE: Obesity is associated with delayed insulin absorption upon subcutaneous (s.c.) dosing in humans. The aim of this study was to investigate whether alterations in depot structure and kinetics of the s.c. injection depot contribute to this delay. METHODS: Rats fed a high‐fat diet (HFD) and l...

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Detalhes bibliográficos
Publicado no:Obes Sci Pract
Main Authors: Gradel, A. K. J., Porsgaard, T., Brockhoff, P. B., Seested, T., Lykkesfeldt, J., Refsgaard, H. H. F.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6587326/
https://ncbi.nlm.nih.gov/pubmed/31275602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/osp4.326
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