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Delayed insulin absorption correlates with alterations in subcutaneous depot kinetics in rats with diet‐induced obesity

OBJECTIVE: Obesity is associated with delayed insulin absorption upon subcutaneous (s.c.) dosing in humans. The aim of this study was to investigate whether alterations in depot structure and kinetics of the s.c. injection depot contribute to this delay. METHODS: Rats fed a high‐fat diet (HFD) and l...

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Publicado en:Obes Sci Pract
Main Authors: Gradel, A. K. J., Porsgaard, T., Brockhoff, P. B., Seested, T., Lykkesfeldt, J., Refsgaard, H. H. F.
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2019
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6587326/
https://ncbi.nlm.nih.gov/pubmed/31275602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/osp4.326
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