CRISPR-induced double-strand breaks trigger recombination between homologous chromosome arms

CRISPR–Cas9–based genome editing has transformed the life sciences, enabling virtually unlimited genetic manipulation of genomes: The RNA-guided Cas9 endonuclease cuts DNA at a specific target sequence and the resulting double-strand breaks are mended by one of the intrinsic cellular repair pathways...

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Vydáno v:Life Sci Alliance
Hlavní autoři: Brunner, Erich, Yagi, Ryohei, Debrunner, Marc, Beck-Schneider, Dezirae, Burger, Alexa, Escher, Eliane, Mosimann, Christian, Hausmann, George, Basler, Konrad
Médium: Artigo
Jazyk:Inglês
Vydáno: Life Science Alliance LLC 2019
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6587125/
https://ncbi.nlm.nih.gov/pubmed/31196871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.201800267
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