The sigma‐1 receptor behaves as an atypical auxiliary subunit to modulate the functional characteristics of Kv1.2 channels expressed in HEK293 cells

Expression of Kv1.2 within Kv1.x potassium channel complexes is critical in maintaining appropriate neuronal excitability and determining the threshold for action potential firing. This is attributed to the interaction of Kv1.2 with a hitherto unidentified protein that confers bimodal channel activa...

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Bibliographic Details
Published in:Physiol Rep
Main Authors: Abraham, Madelyn J., Fleming, Kayla L., Raymond, Sophie, Wong, Adrian Y. C., Bergeron, Richard
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2019
Subjects:
Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6586770/
https://ncbi.nlm.nih.gov/pubmed/31222975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.14147
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