PRE-surgical Metformin In Uterine Malignancy (PREMIUM): a Multi-Center, Randomized Double-Blind, Placebo-Controlled Phase III Trial

PURPOSE: Endometrioid endometrial cancer is strongly associated with obesity and insulin resistance. Metformin,an insulin sensitizer, reduces endometrial tumor growth in vitro. Presurgical window studies allow rapid in vivo assessment of antitumor activity. Previous window studies found metformin re...

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Pubblicato in:Clin Cancer Res
Autori principali: Kitson, Sarah J., Maskell, Zoe, Sivalingam, Vanitha N., Allen, Jennifer L., Ali, Saad, Burns, Sean, Gilmour, Kyle, Latheef, Rahamatulla, Slade, Richard J., Pemberton, Philip W., Shaw, Joseph, Ryder, W. David, Kitchener, Henry C., Crosbie, Emma J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6586555/
https://ncbi.nlm.nih.gov/pubmed/30563932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-3339
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