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The effect of detergent, temperature and lipid on the oligomeric state of MscL constructs: Insights from mass spectrometry

The mechanosensitive channel of large conductance (MscL) acts as an emergency release valve for osmotic shock of bacteria preventing cell lysis. The large pore size, essential for function, requires the formation of oligomers with tetramers, pentamers or hexamers observed depending on the species an...

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Detalhes bibliográficos
Publicado no:Chem Biol
Main Authors: Reading, Eamonn, Walton, Troy A., Liko, Idlir, Marty, Michael T., Laganowsky, Arthur, Rees, Douglas C., Robinson, Carol V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6585436/
https://ncbi.nlm.nih.gov/pubmed/26000747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2015.04.016
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