Targeted Inhibition of Histone Deacetylase Leads to Suppression of Ewing Sarcoma Tumor Growth Through an Unappreciated EWS-FLI1/HDAC3/HSP90 Signaling Axis

Ewing sarcoma (ES) are aggressive pediatric bone and soft tissue tumors driven by EWS-ETS fusion oncogenes, most commonly EWS-FLI1. Treatment of ES patients consists of up to 9 months of alternating courses of 2 chemotherapeutic regimens. Furthermore, EWS-ETS-targeted therapies have yet to demonstra...

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Foilsithe in:J Mol Med (Berl)
Main Authors: Ma, Yan, Baltezor, Michael, Rajewski, Lian, Crow, Jennifer, Samuel, Glenson, Staggs, Vincent S., Chastain, Katherine M., Toretsky, Jeffrey A., Weir, Scott J., Godwin, Andrew K.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2019
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6584050/
https://ncbi.nlm.nih.gov/pubmed/31025088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00109-019-01782-0
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