Small-molecule affinity capture of DNA/RNA quadruplexes and their identification in vitro and in vivo through the G4RP protocol

Guanine-rich DNA and RNA sequences can fold into higher-order structures known as G-quadruplexes (or G4-DNA and G4-RNA, respectively). The prevalence of the G4 landscapes in the human genome, transcriptome and ncRNAome (non-coding RNA), collectively known as G4ome, is strongly suggestive of biologic...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Renard, Isaline, Grandmougin, Michael, Roux, Apolline, Yang, Sunny Y, Lejault, Pauline, Pirrotta, Marc, Wong, Judy M Y, Monchaud, David
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2019
Témata:
Chemical Biology and Nucleic Acid Chemistry
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6582334/
https://ncbi.nlm.nih.gov/pubmed/30949698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz215
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