Effects of insulin and pathway inhibitors on the PI3K-Akt-mTOR phosphorylation profile in acute myeloid leukemia cells

The phosphatidylinositol 3-kinase (PI3K)-Akt-mechanistic target of rapamycin (mTOR) pathway is constitutively activated in human acute myeloid leukemia (AML) cells and is regarded as a possible therapeutic target. Insulin is an agonist of this pathway and a growth factor for AML cells. We characteri...

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Détails bibliographiques
Publié dans:Signal Transduct Target Ther
Auteurs principaux: Nepstad, Ina, Hatfield, Kimberley Joanne, Grønningsæter, Ida Sofie, Aasebø, Elise, Hernandez-Valladares, Maria, Hagen, Karen Marie, Rye, Kristin Paulsen, Berven, Frode S., Selheim, Frode, Reikvam, Håkon, Bruserud, Øystein
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6582141/
https://ncbi.nlm.nih.gov/pubmed/31240133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41392-019-0050-0
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