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Resistance to the Antiproliferative In Vitro Effect of PI3K-Akt-mTOR Inhibition in Primary Human Acute Myeloid Leukemia Cells Is Associated with Altered Cell Metabolism

Constitutive signaling through the phosphatidylinositol-3-kinase-Akt-mechanistic target of rapamycin (PI3K-Akt-mTOR) pathway is present in acute myeloid leukemia (AML) cells. However, AML is a heterogeneous disease, and we therefore investigated possible associations between cellular metabolism and...

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Bibliografiske detaljer
Udgivet i:Int J Mol Sci
Main Authors: Nepstad, Ina, Reikvam, Håkon, Brenner, Annette K., Bruserud, Øystein, Hatfield, Kimberley J.
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5855604/
https://ncbi.nlm.nih.gov/pubmed/29382066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms19020382
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