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Formation of Non-Natural α,α-Disubstituted Amino Esters via Catalytic Michael Addition
The enolate monoanion of amino esters is explored, and the first catalytic Michael addition of α-amino esters is demonstrated. These studies indicate that the acidity of the αC–H is the primary factor determining reactivity. Thus, polyfluorophenylglycine amino esters yield novel α-amino esters in th...
Gardado en:
| Publicado en: | Org Lett |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2018
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6581451/ https://ncbi.nlm.nih.gov/pubmed/30387616 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.8b03161 |
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