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Formation of Non-Natural α,α-Disubstituted Amino Esters via Catalytic Michael Addition

The enolate monoanion of amino esters is explored, and the first catalytic Michael addition of α-amino esters is demonstrated. These studies indicate that the acidity of the αC–H is the primary factor determining reactivity. Thus, polyfluorophenylglycine amino esters yield novel α-amino esters in th...

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Bibliografiske detaljer
Udgivet i:Org Lett
Main Authors: Teegardin, Kip A., Gotcher, Lacey, Weaver, Jimmie D.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6581451/
https://ncbi.nlm.nih.gov/pubmed/30387616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.8b03161
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