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A new route to 2′ (3′)-O-alkyl purine nucleosides
The key intermediate, O(6)-ethylguanosine, was prepared via diazoethane alkylation of guanosine, and isolated in crystalline form in one step. In the presence of SnCl(2), the compound reacts with diazomethane to give the 2′(3′)-O-methyl-O(6)-ethylguanosines in high yield. These are readily fractiona...
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| Publicado en: | Nucleic Acids Res |
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| Autores principales: | , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Oxford University Press
1978
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6581373/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/1.suppl_1.s73 |
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