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A new route to 2′ (3′)-O-alkyl purine nucleosides

The key intermediate, O(6)-ethylguanosine, was prepared via diazoethane alkylation of guanosine, and isolated in crystalline form in one step. In the presence of SnCl(2), the compound reacts with diazomethane to give the 2′(3′)-O-methyl-O(6)-ethylguanosines in high yield. These are readily fractiona...

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Pubblicato in:Nucleic Acids Res
Autori principali: Kuśmierek, J.T., Shugar, D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 1978
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6581373/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/1.suppl_1.s73
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