Synergistic cardiac pathological hypertrophy induced by high-salt diet in IGF-IIRα cardiac-specific transgenic rats

Stress-induced cardiac hypertrophy leads to heart failure. Our previous studies demonstrate that insulin-like growth factor—II receptor (IGF-IIR) signaling is pivotal to hypertrophy regulation. In this study, we show a novel IGF-IIR alternative spliced transcript, IGF-IIRα (150 kDa) play a key role...

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Veröffentlicht in:PLoS One
Hauptverfasser: Chang, Ruey-Lin, Nithiyanantham, Srinivasan, Huang, Chih-Yang, Pai, Pei-Ying, Chang, Tung-Ti, Hu, Lai-Chin, Chen, Ray-Jade, VijayaPadma, V., Kuo, Wei-Wen
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2019
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6581245/
https://ncbi.nlm.nih.gov/pubmed/31211784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0216285
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