pH driven precipitation of quisinostat onto PLA-PEG nanoparticles enables treatment of intracranial glioblastoma

Histone deacetylases (HDACs) are known to be key enzymes in cancer development and progression through their modulation of chromatin structure and the expression and post-translational modification of numerous proteins. Aggressive dedifferentiated tumors, like glioblastoma, frequently overexpress HD...

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Pubblicato in:Colloids Surf B Biointerfaces
Autori principali: Householder, Kyle T., DiPerna, Danielle M., Chung, Eugene P., Luning, Anne Rosa, Nguyen, Duong T., Stabenfeldt, Sarah E., Mehta, Shwetal, Sirianni, Rachael W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6581030/
https://ncbi.nlm.nih.gov/pubmed/29533842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.colsurfb.2018.02.048
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