Alzheimer’s Disease Associated Genes Ankyrin and Tau Cause Shortened Lifespan and Memory Loss in Drosophila

Alzheimer’s disease (AD) is the most common form of dementia and is characterized by intracellular neurofibrillary tangles of hyperphosphorylated Tau, including the 0N4R isoform and accumulation of extracellular amyloid beta (Aβ) plaques. However, less than 5% of AD cases are familial, with many add...

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Bibliografiset tiedot
Julkaisussa:Front Cell Neurosci
Päätekijät: Higham, James P., Malik, Bilal R., Buhl, Edgar, Dawson, Jennifer M., Ogier, Anna S., Lunnon, Katie, Hodge, James J. L.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Frontiers Media S.A. 2019
Aiheet:
Neuroscience
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6581016/
https://ncbi.nlm.nih.gov/pubmed/31244615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2019.00260
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