Adenovirus E1B 55-Kilodalton Protein Targets SMARCAL1 for Degradation during Infection and Modulates Cellular DNA Replication

Here, we show that the cellular DNA replication protein and ATR substrate SMARCAL1 is recruited to viral replication centers early during adenovirus infection and is then targeted in an E1B-55K/E4orf6- and cullin RING ligase-dependent manner for proteasomal degradation. In this regard, we have deter...

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Bibliographische Detailangaben
Veröffentlicht in:J Virol
Hauptverfasser: Nazeer, Reshma, Qashqari, Fadi S. I., Albalawi, Abeer S., Piberger, Ann Liza, Tilotta, Maria Teresa, Read, Martin L., Hu, Siyuan, Davis, Simon, McCabe, Christopher J., Petermann, Eva, Turnell, Andrew S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2019
Schlagworte:
Virus-Cell Interactions
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6580949/
https://ncbi.nlm.nih.gov/pubmed/30996091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00402-19
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