Adenovirus E1B 55-Kilodalton Protein Targets SMARCAL1 for Degradation during Infection and Modulates Cellular DNA Replication

Here, we show that the cellular DNA replication protein and ATR substrate SMARCAL1 is recruited to viral replication centers early during adenovirus infection and is then targeted in an E1B-55K/E4orf6- and cullin RING ligase-dependent manner for proteasomal degradation. In this regard, we have deter...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Nazeer, Reshma, Qashqari, Fadi S. I., Albalawi, Abeer S., Piberger, Ann Liza, Tilotta, Maria Teresa, Read, Martin L., Hu, Siyuan, Davis, Simon, McCabe, Christopher J., Petermann, Eva, Turnell, Andrew S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2019
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6580949/
https://ncbi.nlm.nih.gov/pubmed/30996091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00402-19
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