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Dynamics of Quaternary Structure Transitions in R‑State Carbonmonoxyhemoglobin Unveiled in Time-Resolved X‑ray Scattering Patterns Following a Temperature Jump

It is well-known that tetrameric hemoglobin binds ligands cooperatively by undergoing a ligand-induced T → R quaternary structure transition, a structure−function relationship that has long served as a model system for understanding allostery in proteins. However, kinetic studies of the reverse, R →...

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Veröffentlicht in:J Phys Chem B
Hauptverfasser: Sun Cho, Hyun, Schotte, Friedrich, Stadnytskyi, Valentyn, DiChiara, Anthony, Henning, Robert, Anfinrud, Philip
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6580858/
https://ncbi.nlm.nih.gov/pubmed/30285440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jpcb.8b07414
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