Importance of the Conserved Carboxyl-Terminal CNOT1 Binding Domain to Tristetraprolin Activity In Vivo

Tristetraprolin (TTP) is an anti-inflammatory protein that modulates the stability of certain cytokine/chemokine mRNAs. After initial high-affinity binding to AU-rich elements in 3′ untranslated regions of target mRNAs, mediated through its tandem zinc finger (TZF) domain, TTP promotes the deadenyla...

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Udgivet i:Mol Cell Biol
Main Authors: Lai, Wi S., Stumpo, Deborah J., Wells, Melissa L., Gruzdev, Artiom, Hicks, Stephanie N., Nicholson, Cindo O., Yang, Zhengfeng, Faccio, Roberta, Webster, Michael W., Passmore, Lori A., Blackshear, Perry J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6580703/
https://ncbi.nlm.nih.gov/pubmed/31036567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00029-19
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