Discovery of Irreversible Inhibitors Targeting Histone Methyltransferase, SMYD3

[Image: see text] SMYD3 is a histone methyltransferase that regulates gene transcription, and its overexpression is associated with multiple human cancers. A novel class of tetrahydroacridine compounds which inhibit SMYD3 through a covalent mechanism of action is identified. Optimization of these ir...

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Xehetasun bibliografikoak
Argitaratua izan da:ACS Med Chem Lett
Egile Nagusiak: Huang, Chuhui, Liew, Si Si, Lin, Grace R., Poulsen, Anders, Ang, Melgious J. Y., Chia, Brian C. S., Chew, Sin Yin, Kwek, Zekui P., Wee, John L. K., Ong, Esther H., Retna, Priya, Baburajendran, Nithya, Li, Rong, Yu, Weixuan, Koh-Stenta, Xiaoying, Ngo, Anna, Manesh, Sravanthy, Fulwood, Justina, Ke, Zhiyuan, Chung, Hwa Hwa, Sepramaniam, Sugunavathi, Chew, Xin Hui, Dinie, Nurul, Lee, May Ann, Chew, Yun Shan, Low, Choon Bing, Pendharkar, Vishal, Manoharan, Vithya, Vuddagiri, Susmitha, Sangthongpitag, Kanda, Joy, Joma, Matter, Alex, Hill, Jeffrey, Keller, Thomas H., Foo, Klement
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Chemical Society 2019
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6580565/
https://ncbi.nlm.nih.gov/pubmed/31223458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00170
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