Identification of covalent active site inhibitors of dengue virus protease

Dengue virus (DENV) protease is an attractive target for drug development; however, no compounds have reached clinical development to date. In this study, we utilized a potent West Nile virus protease inhibitor of the pyrazole ester derivative class as a chemical starting point for DENV protease dru...

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Detalhes bibliográficos
Publicado no:Drug Des Devel Ther
Main Authors: Koh-Stenta, Xiaoying, Joy, Joma, Wang, Si Fang, Kwek, Perlyn Zekui, Wee, John Liang Kuan, Wan, Kah Fei, Gayen, Shovanlal, Chen, Angela Shuyi, Kang, CongBao, Lee, May Ann, Poulsen, Anders, Vasudevan, Subhash G, Hill, Jeffrey, Nacro, Kassoum
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2015
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4677662/
https://ncbi.nlm.nih.gov/pubmed/26677315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S94207
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