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Endothelial cell-specific collagen type IV-α(3) expression does not rescue Alport syndrome in Col4a3(−)(/−) mice
The glomerular basement membrane (GBM) is a critical component of the kidney’s blood filtration barrier. Alport syndrome, a hereditary disease leading to kidney failure, is caused by the loss or dysfunction of the GBM’s major collagen type IV (COL4) isoform α(3)α(4)α(5). The constituent COL4 α-chain...
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| izdano v: | Am J Physiol Renal Physiol |
|---|---|
| Main Authors: | , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Physiological Society
2019
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6580247/ https://ncbi.nlm.nih.gov/pubmed/30724107 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00556.2018 |
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