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Endothelial cell-specific collagen type IV-α(3) expression does not rescue Alport syndrome in Col4a3(−)(/−) mice

The glomerular basement membrane (GBM) is a critical component of the kidney’s blood filtration barrier. Alport syndrome, a hereditary disease leading to kidney failure, is caused by the loss or dysfunction of the GBM’s major collagen type IV (COL4) isoform α(3)α(4)α(5). The constituent COL4 α-chain...

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Pubblicato in:Am J Physiol Renal Physiol
Autori principali: Funk, Steven D., Bayer, Raymond H., Miner, Jeffrey H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6580247/
https://ncbi.nlm.nih.gov/pubmed/30724107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00556.2018
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