Betulinic Acid Derivative BA5, Attenuates Inflammation and Fibrosis in Experimental Chronic Chagas Disease Cardiomyopathy by Inducing IL-10 and M2 Polarization

Chronic Chagas disease cardiomyopathy (CCC) is a major cause of heart disease in Latin America and treatment for this condition is unsatisfactory. Here we investigated the effects of BA5, an amide semi-synthetic derivative betulinic acid, in a model of CCC. Mice chronically infected with T. cruzi we...

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Vydáno v:Front Immunol
Hlavní autoři: Meira, Cássio Santana, Santos, Emanuelle De Souza, Santo, Renan Fernandes do Espírito, Vasconcelos, Juliana Fraga, Orge, Iasmim Diniz, Nonaka, Carolina Kymie Vasques, Barreto, Breno Cardim, Caria, Alex Cleber Improta, Silva, Daniela Nascimento, Barbosa-Filho, José Maria, Macambira, Simone Garcia, Moreira, Diogo Rodrigo Magalhães, Soares, Milena Botelho Pereira
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2019
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6579897/
https://ncbi.nlm.nih.gov/pubmed/31244833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.01257
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