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Polygenic Disease and Retinitis Pigmentosa: Albinism Exacerbates Photoreceptor Degeneration Induced by the Expression of a Mutant Opsin in Transgenic Mice
Expression of a mouse opsin transgene containing three point mutations (V20G, P23H, and P27L; termed VPP) causes a progressive photoreceptor degeneration that resembles in many important respects that seen in patients with autosomal dominant retinitis pigmentosa caused by a P23H point mutation. We h...
Gespeichert in:
| Veröffentlicht in: | J Neurosci |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Society for Neuroscience
1996
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6579236/ https://ncbi.nlm.nih.gov/pubmed/8987813 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.16-24-07853.1996 |
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