Systemic Administration of a Nerve Growth Factor Conjugate Reverses Age-Related Cognitive Dysfunction and Prevents Cholinergic Neuron Atrophy

Intraventricular administration of nerve growth factor (NGF) in rats has been shown to reduce age-related atrophy of central cholinergic neurons and the accompanying memory impairment. Intraventricular administration of NGF is necessary because NGF will not cross the blood–brain barrier (BBB). Here...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Bäckman, Cristina, Rose, Gregory M., Hoffer, Barry J., Henry, Michael A., Bartus, Raymond T., Friden, Phillip, Granholm, Ann-Charlotte
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 1996
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6578877/
https://ncbi.nlm.nih.gov/pubmed/8757256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.16-17-05437.1996
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