11 beta-Hydroxysteroid dehydrogenase in cultured hippocampal cells reactivates inert 11-dehydrocorticosterone, potentiating neurotoxicity

11 beta-Hydroxysteroid dehydrogenase (11 beta-HSD) catalyzes the conversion of the glucocorticoid corticosterone (cortisol in humans) to inert 11-dehydrocorticosterone (cortisone). 11 beta-HSD activity is present in the hippocampus, where it is induced by glucocorticoids and stress in vivo, promptin...

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Vydáno v:J Neurosci
Hlavní autoři: Rajan, V, Edwards, CR, Seckl, JR
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 1996
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Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6578723/
https://ncbi.nlm.nih.gov/pubmed/8613810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.16-01-00065.1996
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