Blockade of neuronal nitric oxide synthase protects against excitotoxicity in vivo

Nitric oxide may be a key mediator of excitotoxic neuronal injury in the central nervous system. We examined the effects of the neuronal nitric oxide synthase inhibitor 7-nitroindazole (7-NI) on excitotoxic striatal lesions. 7-NI significantly attenuated lesions produced by intrastriatal injections...

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Publicat a:J Neurosci
Autors principals: Schulz, JB, Matthews, RT, Jenkins, BG, Ferrante, RJ, Siwek, D, Henshaw, DR, Cipolloni, PB, Mecocci, P, Kowall, NW, Rosen, BR
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 1995
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6577929/
https://ncbi.nlm.nih.gov/pubmed/8613773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.15-12-08419.1995
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