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Phenotypic heterogeneity and evolution of melanoma cells associated with targeted therapy resistance
Phenotypic plasticity is associated with non-genetic drug tolerance in several cancers. Such plasticity can arise from chromatin remodeling, transcriptomic reprogramming, and/or protein signaling rewiring, and is characterized as a cell state transition in response to molecular or physical perturbat...
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| Publicado no: | PLoS Comput Biol |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6576794/ https://ncbi.nlm.nih.gov/pubmed/31166947 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1007034 |
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