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Deciphering regulatory DNA sequences and noncoding genetic variants using neural network models of massively parallel reporter assays

The relationship between noncoding DNA sequence and gene expression is not well-understood. Massively parallel reporter assays (MPRAs), which quantify the regulatory activity of large libraries of DNA sequences in parallel, are a powerful approach to characterize this relationship. We present MPRA-D...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Movva, Rajiv, Greenside, Peyton, Marinov, Georgi K., Nair, Surag, Shrikumar, Avanti, Kundaje, Anshul
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6576758/
https://ncbi.nlm.nih.gov/pubmed/31206543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0218073
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