Heterozygosity at the canarc-1 locus can confer susceptibility for narcolepsy: induction of cataplexy in heterozygous asymptomatic dogs after administration of a combination of drugs acting on monoaminergic and cholinergic systems

Narcolepsy is a genetically determined disorder of sleep characterized by excessive daytime sleepiness and abnormal manifestations of REM sleep that affects both humans and animals. Although its exact pathophysiologic mechanisms remain undetermined, recent experiments have demonstrated that in both...

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Publicat a:J Neurosci
Autors principals: Mignot, E, Nishino, S, Sharp, LH, Arrigoni, J, Siegel, JM, Reid, MS, Edgar, DM, Ciaranello, RD, Dement, WC
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 1993
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6576622/
https://ncbi.nlm.nih.gov/pubmed/8095066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.13-03-01057.1993
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