Human cGAS catalytic domain has an additional DNA-binding interface that enhances enzymatic activity and liquid-phase condensation

The cyclic GMP-AMP synthase (cGAS)–cGAMP–STING pathway plays a key role in innate immunity, with cGAS sensing both pathogenic and mislocalized DNA in the cytoplasm. Human cGAS (h-cGAS) constitutes an important drug target for control of antiinflammatory responses that can contribute to the onset of...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Xie, Wei, Lama, Lodoe, Adura, Carolina, Tomita, Daisuke, Glickman, J. Fraser, Tuschl, Thomas, Patel, Dinshaw J.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2019
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PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6575157/
https://ncbi.nlm.nih.gov/pubmed/31142647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1905013116
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